Calcium phosphates are manufactured by using a very pure grade of phosphoric acid which is reacted with calcium hydroxide derived from limestone. When calcium hydroxide is added to phosphoric acid in the appropriate ratio, dicalcium phosphate (DCP) is precipitated. On the other hand, when acid is added to calcium hydroxide, the precipitate is tricalcium phosphate (TCP) which contains the highest level of calcium content.
After drying, the resulting granular grades can be further milled to obtain a powder grade. The ‘milled’ or ‘powder’ grade is typically used in wet granulation processes while the ‘unmilled’ or ‘granular’ grade is used for direct compression.
CALIPHARM A / D / T
Brand of
Dicalcium phosphate USP/NF, EP, JP
| Types | Calcium (%) / Phosphorus (%) | Applications |
| DCP, anhydrous granular | 29.0 / 22.2 | Tablet and capsule diluent for direct compression. Is non-hygroscopic and stable at room temperature resulting in better product stability |
| DCP, anhydrous powder | 29.0 / 22.2 | Filler in wet granulation, vitamin premixes and nutritional drinks |
| DCP, dihydrate granular | 23.3 / 18.1 | Tablet and capsule diluent for direct compression, blend densifier, tablet punch polishing agent, time-release agent and a carrier of actives |
| DCP, dihydrate powder | 23.3 / 18.1 | Filler in wet granulation, vitamin premixes and nutritional drinks |
Tricalcium phosphate USP/NF, EP
| Types | Calcium (%) / Phosphorus (%) | Applications |
| TCP, anhydrous granular | 38.0 / 17.3 | Tablet and capsule diluent for direct compression, glidant due to its high surface area and carrier of actives. Ideal for formulations requiring high calcium content |
| TCP, anhydrous powder | 38.0 / 17.3 | Filler in wet granulation particularly antacid formulations for its buffer action. Used in nutritional drinks and for formulations requiring calcium / phosphorus fortification |
Tricalcium phosphate FCC
| Types | Advantages | Applications |
| TCP, anhydrous micronized powder | Provides fortification without grittiness due to its controlled particle size of less than 10 - 12 μm | Soft chews and gummies |
Co-processed calcium phosphates
Innophos co-processed excipients serve multiple functions and thus simplify formulation, increases process efficiency and reduce tablet size. These excipients provide excellent flow, compressibility and enhanced organoleptic properties
| Compositions | Applications |
| Compound of Tricalcium phosphate USP/NF, EP (96%) and Polyvinylpyrrolidone USP/NP, EP (4%) | Used in direct compression process for pharmaceutical and nutraceutical application such as multivitamins & dietary supplements, chewable tablets, source of calcium and phosphorous |
| Compound of Dicalcium phosphate, anhydrous USP/NF, EP, JP and Maltodextrin USP/NF | Used in direct compression process for pharmaceutical and nutraceutical application such as multivitamins & dietary supplements, chewable tablets, source of calcium and phosphorous |
| Compound of Tricalcium phosphate (∼96%) USP/NF and Guar gum (∼4%) FCC | Used in direct compression process for pharmaceutical and nutraceutical application such as multivitamins & dietary supplements, chewable tablets, source of calcium and phosphorous |
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