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KLEPTOSE HPB/HP

Brand of

Hydroxypropyl Betadex USP/NF, EP

Kleptose HPB and Kleptose HP are purified, polydisperse product resulting from controlled reaction of propylene oxide and native betadex under base catalysis. This product overcomes the low solubility and inadequate biological tolerance of the native betacyclodextrin molecule. These products are produced in a purpose built, state-of-the-art manufacturing plant following USFDA type GMP quality guidelines and is well supported by toxicology data.
Molecular Substitutions Residual Betadex Contents Applications
0.58 – 0.68 1.5% Suitable for parenteral use, syrups, solutions and oral suspensions as well as for dry formulations (with possibility of in-situ encapsulation). Increases water solubility of poorly soluble drugs thereby improving bioavailability and enhances organoleptic properties of bitter or unpleasant actives. Separate grades are available for oral and parenteral applications.
0.81 – 0.99 1.5% Suitable for parenteral use, syrups, solutions and oral suspensions as well as for dry formulations (with possibility of in-situ encapsulation). Increases water solubility of poorly soluble drugs thereby improving bioavailability and enhances organoleptic properties of bitter or unpleasant actives. Separate grades are available for oral and parenteral applications.
0.50-0.71 0.3% Low betadex content grade. Acts as stabilizer against light and oxidation and solubility enhancer for active substances in parenteral formulations. Also complies to ChP monograph

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