Sol International Private Limited

KOLLIPHOR CS

Brand of

Macrogol Cetostearyl Ether and Cetostearyl Alcohol, Emulsifying

Kolliphor CS 12 and CS 20 are polyoxyethylene alkyl ethers prepared by the condensation of linear fatty alcohols derived from vegetable sources with ethylene oxide. The reaction is a controlled one, so that the required ether is formed with the polyethylene glycol of desired molecular weight.

Kolliphor CS A is an anionic emulsifying wax prepared by melting cetostearyl alcohol and heating to about 95°C. Purified water and suitable anionic surfactant i.e. sodium cetostearyl sulphate is added and this mixture is further heated upto 115°C with vigorous stirring until frothing ceases. The resulting wax is then rapidly cooled.
Pharmacopeial Names Applications
Macrogol cetostearyl ether 12 EP Non-ionic emulsifier for topical dosage forms. Can be formulated in hot processes as well as phase inversion technology (PIT) and stable with a broad pH range
Polyoxyl 20 cetostearyl ether USP/NF, EP Non-ionic emulsifier for topical dosage forms. Can be formulated in hot processes as well as phase inversion technology (PIT) and stable with a broad pH range
Cetostearyl alcohol (Type A), emulsifying EP Anionic self-emulsifying base for topical emulsions

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